What foods should you avoid while on Zepbound?

Instagram vs. reality can be pretty far apart for most things. See: spotless entryways, 18-step morning routines, vacations with kids, and — if we’re really honest — losing weight on a medication like tirzepatide. Social media is packed with misinformation about taking weight-loss medications, including that your food choices don’t matter because you’ll lose weight no matter what.

Zepbound, which has the active ingredient tirzepatide and is FDA-approved for weight loss, dials down how hungry you feel and can lead you to eat less. But, like other GLP-1 medications, you still need to pay close attention to what’s on your plate — to mitigate side effects, support your weight loss, and boost your overall well-being. Here’s how.

Zepbound is similar to otherGLP-1weight-loss medications like semaglutide (Wegovy) and liraglutide (Saxenda). These medications work by mimicking agut hormonecalled GLP-1 (short for glucagon-like peptide-1). GLP-1 helps control your blood sugar, curb appetite, and slow stomach emptying when you eat — effects that are extended for hours when you take a GLP-1 agonist. Unlike semaglutide, Zepbound also targets glucose-dependent insulinotropic polypeptide (GIP) receptors in the stomach and brain.

When combined, GLP-1 and GIP can boost one another’s effects, working together to suppress your appetite and reduce cravings better than each alone. “Unlike GLP-1, GIP also reduces acid production in the stomach, which slows down the digestion of food, and restores the body’s sensitivity to insulin,” says Dr. Caroline Messer, M.D., a professor of medicine, endocrinology, diabetes, and bone disease at Icahn School of Medicine at Mount Sinai in New York City. GIP may also have a direct effect on increasing the amount of fat burned, she says. Research has found that people on the highest dose of tirzepatide (15mg) can lose an average of 21% of their weight after around a year and a half.

GLP-1 agonists like Zepbound partly work in the gut, which is why many of their potential side effects are gastrointestinal in nature. Possible side effects include:

• Abdominal pain

• Constipation

• Diarrhea

• Nausea

• Upset stomach

• Vomiting

For a complete list of side effects, please visit the Zepbound websitehere.

Because side effects are mostly gastrointestinal, it makes sense that certain foods can make them worse. Generally speaking, “foods that slow gastric emptying, like tirzepatide, can increase side effects,” says Dr. Holly Lofton, M.D., professor of medicine and surgery at NYU Grossman School of Medicine and the director of the Medical Weight Management Program at NYU Langone Health in New York City. If a medication keeps food in your stomach for longer, eating foods that also prolong that process can intensify stomach issues.

These are some of the types of foods to watch out for.

1. Alcoholhas calories but doesn’t provide any nutrients and drinks with a high alcohol content (such as those above 15%) can slow gastric emptying.
   
   

2. Greasy or fatty foods, such as pizza and French fries, can make you feel overly full and are digested slowly, increasing the risk of nausea, vomiting, and heartburn.
   
   

3. Soda and other carbonated drinkscan increase the risk of nausea and acid reflux.
   
   

4. Sugary and highly processed foodsmay not make side effects worse, but they can fill you up without supplying you with the nutrients you need — like fiber, vitamins, and protein.
   
   

5. Spicy foodscan exacerbate acid reflux, especially if you already had acid reflux before getting on theweight-loss medications.

As always, please consult your healthcare provider before making dietary changes. And not everyone will react the same to all foods, so it’s worthwhile to notice which of the above makes you feel worse. Then, be more mindful about when you eat those foods.

While there’s no single “Zepbound diet” to follow, eating strategically can help you feel more comfortable. For instance, staying hydrated and eating plenty of fiber are both shown to help reduce the risk of constipation, according to Messer. At the same time, protein can help you hold on to your muscle while losing weight. That means you should reach for foods like vegetables and fruits (which are full of nutrients and fiber) plus whole grains, lean meats, seafood, eggs, tofu, and beans (which are rich in fiber and protein).

It’s important to pair tirzepatide medications like Zepbound with healthy lifestyle changes, especially strength training. “As patients lose weight, they inevitably lose muscle,” says Messer. “For this reason, I recommend both aerobic and resistance exercises to increase muscle tone.”

These habits can benefit both weight loss and your overall health. (Remember: The goal is betterweight health, which is when you feel your best and improve your quality of life.) Plus, healthy habits can also be helpful if you ever decide to stop taking Zepbound. The latest research has found that stopping tirzepatide can cause people to regain two-thirds of the weight they lost within a year. This is a big reason why these medications are designed for long-term use.

You don’t need to try to make these new lifestyle changes alone. TheWeightWatchers GLP1 Companion Programis designed to help you prioritize these healthy habits — eating more protein and fiber, staying hydrated, and exercising regularly — while WeightWatchers Clinic can help if you need more one-on-one help with board-certified doctors, registered dietitians, and fitness coaches.

Like all GLP-1s, Zepbound comes with the potential for side effects such as constipation and nausea (for a complete list of side effects, please visit the Zepbound websitehere). But paying attention to your diet, like by limiting high-fat meals and prioritizing nutrient-dense foods high in protein and fiber, can possibly help reduce those side effects. Those smarter food choices, along with other lifestyle changes like increasing your exercise, will help you gain health and feel great while losing weight on aweight-loss program.