The link between GERD and GLP-1 medications

Beyond simply feeling unpleasant, this recurrent reflux can lead to complications down the road. Here’s how to get a handle on it.

By Weight Watchers

Last updated March 31, 2025

The link between GERD and GLP-1 medications

This content is for informational purposes only and does not constitute medical advice, diagnosis or treatment. It should not be regarded as a substitute for guidance from your healthcare provider.

WeightWatchers relies on only the most trustworthy sources, including highly credentialed experts, government and academic institutions, peer-reviewed studies, and respected medical associations. We focus on primary sources and research that is recent, relevant, and high-quality. For more about how we report, write, and fact check our stories, please see our editorial policy.

GLP-1s and GERD: Gut (2024.) “Shorter-acting glucagon-like peptide-1 receptor agonists are associated with increased development of gastro-oesophageal reflux disease and its complications in patients with type 2 diabetes mellitus.” GERD overview:National Institute of Diabetes and Digestive and Kidney Diseases. “Acid Reflux (GER & GERD) in Adults.” GERD medications and vitamin B-12 deficiency:Adv Nutr (2018.) “Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency.”https://pmc.ncbi.nlm.nih.gov/articles/PMC6054240/

https://www.niddk.nih.gov/health-information/digestive-diseases/acid-reflux-ger-gerd-adults

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The link between GERD and GLP-1 medications

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